100.0 nanograms of DNA per milligram of tissue, against 6.4 and 1.8 nanograms from two other rapid extraction kits tested on the same mouse tail tips.

That gap came from a head-to-head comparison run in a transgenic mouse facility, where prepGEM Tissue was tested against two commercially available rapid DNA extraction kits on the same sex-determination assay, across three different PCR chemistries.

The yield difference was the more visible result. The more useful one was what happened next: DNA from one competitor kit inhibited PCR when paired with anything other than that kit's own proprietary reagents. prepGEM-extracted DNA amplified cleanly across all three chemistries tested, with no smearing or migration distortion on the gel.

The likely explanation is the absence of alkali, chaotropic salts, or detergents in the extraction step, substances that can carry over and interfere with downstream reactions even when yield looks adequate on paper.

Other kits ask you to build your downstream PCR around their chemistry. prepGEM does not. Roughly fifteen times the yield of the nearest competitor tested, and clean amplification regardless of which PCR reagents your lab already trusts.