03.04.2025

5 Mins

The Hidden Cost of Legacy DNA Extraction Methods

person holding black round plate

Mark Gonzales

Data Officer

Why lab managers are rethinking their extraction workflows

For decades, laboratories have relied on the same DNA extraction methods—protocols developed in an era when speed and sustainability weren't priorities. Today's labs face mounting pressure: tighter budgets, higher sample volumes, and growing environmental responsibility. Yet many continue using workflows that generate excessive plastic waste, require hazardous chemicals, and consume hours of valuable lab time.

The problem isn't just inefficiency—it's invisibility. Lab managers often don't realize how much time and money they're losing to outdated extraction methods. A typical extraction protocol takes 2-4 hours of active processing time, requires multiple tube transfers (each increasing contamination risk), and generates significant plastic waste from columns, tubes, and tips.

Modern alternatives exist. New extraction chemistries can reduce processing time to minutes, eliminate toxic reagents, and dramatically reduce plastic consumption—all while maintaining or improving purity and yield. The question isn't whether to upgrade, but how to do it without disrupting validated workflows or risking accreditation.

For labs ready to modernize, the path forward starts with understanding what's possible when chemistry evolves beyond legacy methods.